chemistry

There was something ghost-like and insubstantial about gases to these early chemists. They called liquids that turned into gases easily, "spirits." Methyl alcohol, they called "wood spirit"; ethyl alcohol, "wine spirit." Even today, alcoholic beverages are frequently referred to as "spirits." (Modern Arabs, from whose language the word "alcohol" was taken, call ethyl alcohol "spirit" from the English. This is a queer exchange.)

This theory [the oxygen theory] is not as I have heard it described, that of the French chemists, it is mine (elle est la mienne); it is a property which I claim from my contemporaries and from posterity.

At my urgent request the Curie laboratory, in which radium was discovered a short time ago, was shown to me. The Curies themselves were away travelling. It was a cross between a stable and a potato-cellar, and, if I had not seen the worktable with the chemical apparatus, I would have thought it a practical joke.(Wilhelm Ostwald on seeing the Curie's laboratory facilities.)

In chemistry, our theories are crutches; to show that they are valid, they must be used to walk... A theory established with the help of twenty facts must explain thirty, and lead to the discovery of ten more.

The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.

A demonstrative and convincing proof that an acid does consist of pointed parts is, that not only all acid salts do Crystallize into edges, but all Dissolutions of different things, caused by acid liquors, do assume this figure in their Crystallization; these Crystalls consist of points differing both in length and bigness from one another, and this diversity must be attributed to the keener or blunter edges of the different sorts of acids.

Will fluorine ever have practical applications?It is very difficult to answer this question. I may, however, say in all sincerity that I gave this subject little thought when I undertook my researches, and I believe that all the chemists whose attempts preceded mine gave it no more consideration.A scientific research is a search after truth, and it is only after discovery that the question of applicability can be usefully considered.

During this time (at high school) I discovered the Public Library... It was here that I found a source of knowledge and the means to acquire it by reading, a habit of learning which I still follow to this day. I also became interested in chemistry and gradually accumulated enough test tubes and other glassware to do chemical experiments, using small quantities of chemicals purchased from a pharmacy supply house. I soon graduated to biochemistry and tried to discover what gave flowers their distinctive colours. I made the (to me) astounding discovery that the pigments I extracted changed their colours when I changed the pH of the solution.

It has been demonstrated that a species of penicillium produces in culture a very powerful antibacterial substance which affects different bacteria in different degrees. Generally speaking it may be said that the least sensitive bacteria are the Gram-negative bacilli, and the most susceptible are the pyogenic cocci ... In addition to its possible use in the treatment of bacterial infections penicillin is certainly useful... for its power of inhibiting unwanted microbes in bacterial cultures so that penicillin insensitive bacteria can readily be isolated.

I studied calculus for the first time, which to me was an amazingly empowering experience which I could really see how you could understand all sorts of things, and I decided that chemistry and biology just had too much memory for me to be interested. Physics was very easy.

Planck...and Bohr...have invented systems containing electrons of which the motion produces no effect upon external charges...[N]ot only [is this] inconsistent with the accepted laws of electromagnetism, but I may add, is logically objectionable, for that state of motion which produces no physical effect whatsoever may better be called a state of rest.

The dogma of the impossibility of determining the atomic constitution of substances, which until recently was advocated with such fervor by the most able chemists, is beginning to be abandoned and forgotten; and one can predict that the day is not far in the future when a sufficient collection of facts will permit determination of the internal architecture of molecules. A series of experiments directed toward such a goal is the object of this paper.

Chemistry is the dirty part of physics.

In the last four days I have got the (results) given by Tantalum, Chromium, Manganese, Iron , Nickel, Cobalt and Copper ... The chief result is that ... the result for any metal (is) quite easy to guess from the results for the others. This shews that the insides of all the atoms are very much alike, and from these results it will be possible to find out something of what the insides are made up of.

We are at the dawn of a new era, the era of 'molecular biology' as I like to call it, and there is an urgency about the need for more intensive application of physics and chemistry, and specially of structure analysis, that is still not sufficiently appreciated.

That the nobility of Man, acquired in a hundred centuries of trial and error, lay in making himself the conquerer of matter, and that I had enrolled in chemistry because I wanted to maintain faithful to that nobility. That conquering matter is to understand it, and understanding matter is necessary to understanding the universe and ourselves: and that therefore Mendeleev__ Periodic Table, which just during those weeks we were laboriously learning to unravel, was poetry, loftier and more solemn than all the poetry we had swallowed doen in liceo; and come to think of it, it even rhymed! _[T]he chemistry and physics on which we fed, besides being in themselves nourishments vital in themselves, were the antidotes to Fascism _ because they were clear and distinct and verifiable at every step, and not a tissue of lies and emptiness like the radio and newspapers.

Science began with a gadget and a trick. The gadget was the wheel; the trick was fire. We have come a long way from the two-wheel cart to the round-the-world transport plane, or from the sparking flint to man-made nuclear fission. Yet I wonder whether the inhabitants of Hiroshima were more aware of the evolution of science than ancient man facing an on-storming battle chariot.It isn't physics that will make this a better life, nor chemistry, nor sociology. Physics may be used to atom-bomb a nation and chemistry may be used to poison a city and sociology has been used to drive people and classes against classes. Science is only an instrument, no more than a stick or fire or water that can be used to lean on or light or refresh, and also can be used to flail or burn or drown. Knowledge without morals is a beast on the loose.

[The] structural theory is of extreme simplicity. It assumes that the molecule is held together by links between one atom and the next: that every kind of atom can form a definite small number of such links: that these can be single, double or triple: that the groups may take up any position possible by rotation round the line of a single but not round that of a double link: finally that with all the elements of the first short period [of the periodic table], and with many others as well, the angles between the valencies are approximately those formed by joining the centre of a regular tetrahedron to its angular points. No assumption whatever is made as to the mechanism of the linkage. Through the whole development of organic chemistry this theory has always proved capable of providing a different structure for every different compound that can be isolated. Among the hundreds of thousands of known substances, there are never more isomeric forms than the theory permits.