paradigm

Copernicus, Galileo, and Kepler did not solve an old problem, they asked a new question, and in doing so they changed the whole basis on which the old questions had been framed.

It is time to change the paradigm of the church and of every Christian

Female monsters take things as personally as they really are. They study facts. Even if rejection makes them feel like the girl who's not invited to the party, they have to understand the reasons why.... Every question, once it's formulated, is a paradigm, contains its own internal truth. We have to stop diverting ourselves with false questions. And I told Warren: I aim to be a female monster too.

Future is mobile computing - smartphones and tablets are just elements of it. The industry is on the verge of a whole new paradigm.

Ideas that require people to reorganize their picture of the world provoke hostility.

Perfection is a paradigm meant to keep us striving and learning and growing. Like a wondrous sunset, perfection may be beyond our reach, but it is within our view and well worth seeking after.

McKusick's belief in this paradigm-the focus on disability rather than abnormalcy-was actualized in the treatment of patients in his clinic. Patients with dwarfism, for instance, were treated by an interdisciplinary team of genetic counselors, neurologists, orthopedic surgeons, nurses, and psychiatrists trained to focus on specific disabilities of persons with short stature. Surgical interventions were reserved to correct specific deformities as they arose. The goal was not to restore "normalcy"-but vitality, joy, and function. McKusic had rediscovered the founding principles of modern genetics in the realm of human pathology. In humans as in wild flies, genetic variations abounded. Here too genetic variants, environments, and gene-environment interactions ultimately collaborated to cause phenotypes-except in this case, the "phenotype" in question was disease. Here too some genes had partial penetrance and widely variable expressivity. One gene could cause many diseases, and one disease could be caused by many genes. And here too "fitness" could not be judged in absolutes. Rather the lack of fitness-illness [italicized, sic] in colloquial terms- was defined by the relative mismatch between an organism and environment.

It appears that the paradigm of the modern Church has mainly been based on some fragments of the truth rather than the comprehensive totality of understanding God and His Kingdom