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Any important disease whose causality is murky, and for which treatment is ineffectual, tends to be awash in significance. First, the subjects of deepest dread (corruption, decay, pollution, anomie, weakness) are identified with the disease. The disease itself becomes a metaphor. Then, in the name of the disease (that is, using it as a metaphor), that horror is imposed on other things. The disease becomes adjectival. Something is said to be disease-like, meaning that it is disgusting or ugly.
Susan Sontag Illness as Metaphor & AIDS and Its Metaphors
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Any important disease whose causality is murky, and for which treatment is ineffectual, tends to be awash in significance. First, the subjects of deepest dread (corruption, decay, pollution, anomie, weakness) are identified with the disease. The disease itself becomes a metaphor. Then, in the name of the disease (that is, using it as a metaphor), that horror is imposed on other things. The disease becomes adjectival. Something is said to be disease-like, meaning that it is disgusting or ugly.
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Susan Sontag

Illness as Metaphor & AIDS and Its Metaphors

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As Roran watched, the man's arms, neck, and chest shriveled, and his bones appeared in sharp relief-from the bowlike curve of his collarbones to the hollow saddle of his hips, where his stomach hung like an empty waterskin. His lips puckered and drew back farther than they were intended to over his yellow teeth, baring them in a grisly snarl, while his eyeballs deflated as if they were engorged ticks being squished empty of blood, and the surrounding flesh sank inward.

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... on the historical scale, the damages wrought by individual violence for selfish motives are insignificant compared to the holocausts resulting from self-transcending devotion to collectively shared belief-systems. It is derived from primitive identification instead of mature social integration; it entails the partial surrender of personal responsibility and produces the quasi-hypnotic phenomena of group-psychology.

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She wrote, in the last pages, of feeling all the evil of the neighborhood around her. Rather, she wrote obscurely, good and evil are mixed together and reinforce each other in turn. Marcello, if you thought about it, was really a good arrangement, but the good tasted of the bad and the bad tasted of the good, it was a mixture that took your breath away. A few evenings earlier, something had happened that had really scared her. Marcello had left, the television was off, the house was empty, Rino was out, her parents were going to bed. She was alone in the kitchen washing the dishes and was tired, really without energy, when there was an explosion. She had turned suddenly and realized that the big copper pot had exploded. Like that, by itself. It was hanging on the nail where it normally hung, but in the middle there was a large hole and the rim was lifted and twisted and the pot itself was all deformed, as if it could no longer maintain its appearance as a pot. Her mother had hurried in in her nightgown and blamed her for dropping it and ruining it. But a copper pot, even if you drop it, doesn't break and doesn't become misshapen like that. "It's this sort of thing," Lila concluded, "that frightens me. More than Marcello, more than anyone. And I feel that I have to find a solution, otherwise, everything, one thing after another, will break, everything, everything.

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