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But the saddest difference between them was that Zazetsky, as Luria said, 'fought to regain his lost faculties with the indomitable tenacity of the damned,' whereas Dr P. was not fighting, did not know what was lost. But who was more tragic, or who was more damned -- the man who knew it, or the man who did not?
Oliver Sacks The Man Who Mistook His Wife for a Hat and Other Clinical Tales
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But the saddest difference between them was that Zazetsky, as Luria said, 'fought to regain his lost faculties with the indomitable tenacity of the damned,' whereas Dr P. was not fighting, did not know what was lost. But who was more tragic, or who was more damned -- the man who knew it, or the man who did not?
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Oliver Sacks

The Man Who Mistook His Wife for a Hat and Other Clinical Tales

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Had Moreau had any intelligible object, I could have sympathized at least a little with him. I am not so squeamish about pain as that. I could have forgiven him a little even, had his motive been only hate. But he was so irresponsible, so utterly careless! His curiosity, his mad, aimless investigations, drove him on; and the Things were thrown out to live a year or so, to struggle and blunder and suffer, and at last to die painfully.